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Strength Price (Per Unit) Click Below For Prices

10 mg

$0.39  -  $2.30

20 mg

$0.55  -  $3.30

30 mg

$1.27  -  $2.63

Online Aciphex prices listed are typically lower than those found on other popular price comparison websites. You will find international and Canadian online pharmacy prices, in addition to U.S. pharmacy prices available with a prescription discount card, for brand and generic medications.

What is AcipHex?

AcipHex (rabeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

AcipHex is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old.

AcipHex is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. Rabeprazole is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid).

AcipHex may also be given with an antibiotic to prevent duodenal ulcer caused by infection with Helicobacter pylori (H. pylori).

This medicine is not for immediate relief of heartburn symptoms.

GERD and Heartburn: What Is GERD?
SLIDESHOW
GERD and Heartburn: What Is GERD?
Important information
You should not use AcipHex if you are allergic to rabeprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix). AcipHex is not for immediate relief of heartburn symptoms.

Some conditions are treated with a combination of AcipHex and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Rabeprazole can cause kidney problems, an intestinal infection, or lupus (an autoimmune disorder).

Call your doctor right away if you have new or worsening joint pain, a skin rash that gets worse in sunlight, severe stomach pain, watery or bloody diarrhea, blood in your urine, or little or no urination.

Taking AcipHex may increase your risk of bone fracture in the hip, wrist, or spine, especially if you take the medicine long term or more than once per day.

Before taking this medicine
Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

You should not use AcipHex if you are allergic to rabeprazole or:

if you also take any medicine that contains rilpivirine, such as Edurant or Complera; or

if you also allergic to medicines like rabeprazole, such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix).

To make sure AcipHex is safe for you, tell your doctor if you have ever had:

liver disease;

osteoporosis or low bone mineral density (osteopenia);

lupus (an autoimmune disorder); or

low levels of magnesium in your blood.

Taking a proton pump inhibitor such as AcipHex may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medicine long term or more than once per day, and in those who are age 50 and older. It is not clear whether AcipHex is the actual cause of an increased risk of fracture.



It is not known whether AcipHex will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether rabeprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take AcipHex?
AcipHex is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

AcipHex is for short-term use only, usually 4 to 8 weeks. Your doctor may recommend a second course of treatment if you need additional healing time.

Do not give this medicine to a child without medical advice. Certain forms and strengths of rabeprazole should not be given to a child younger than 12 years old.

AcipHex Sprinkle should not be given to a child younger than 1 year old.

When treating H. pylori infection, AcipHex may be needed for only 7 days. Follow your doctor's dosing instructions very carefully.

Take this medicine with a full glass of water.

If you take AcipHex to treat duodenal ulcers, take the medicine after a meal. If you take AcipHex to prevent ulcers caused by Helicobacter pylori, take the medicine with food. If you take this medicine for any other condition, you may take rabeprazole with or without food.

AcipHex Sprinkle delayed-release capsules should be taken 30 minutes before a meal.

Do not crush, break, or chew the tablet form of this medicine. Swallow the tablet whole.

To take AcipHex Sprinkle, open the capsule and sprinkle the medicine into a spoonful of soft food such as applesauce, yogurt, or baby food made from fruit or vegetable. You may also mix the medicine with apple juice, Pedialyte, or infant formula. Swallow right away without chewing. Do not save the mixture for later use; it will go bad after 15 minutes.

Some conditions are treated with a combination of rabeprazole and antibiotics. Use all medications as directed by your doctor. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Do not change your doses or medication schedule without your doctor's advice.

Take your medicine for the full prescribed length of time. Your symptoms may improve before your condition is completely cleared.

Rabeprazole can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

Call your doctor if your symptoms do not improve, or if they get worse while using AcipHex.

If you use AcipHex for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Store at room temperature away from moisture and heat.

See also: Dosage Information (in more detail)

What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking AcipHex?
This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.



Rabeprazole side effects
Get emergency medical help if you have signs of an allergic reaction to AcipHex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

sudden pain or trouble moving your hip, wrist, or back;

seizure (convulsions);

kidney problems - urinating less than usual, blood in your urine, swelling, rapid weight gain;

symptoms of lupus - new or worsening joint pain, skin rash on your cheeks and arms (worsens in sunlight);

symptoms of low magnesium - dizziness, irregular heart rate, feeling jittery, muscle pain or weakness, muscle spasms in your hands and feet, choking feeling, hoarse voice, seizure;

symptoms of low vitamin B - pale skin, tiredness, muscle weakness, irregular heartbeats, feeling light-headed or short of breath; or

signs of bleeding (if you also take warfarin) - headaches, dizziness, weakness; pain or swelling; bruising, unusual bleeding, nosebleeds, bleeding gums); red or pink urine; heavy menstrual flow; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or any bleeding that will not stop.

Common AcipHex side effects may include:

headache;

sore throat;

diarrhea, constipation; or

stomach pain, gas, nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect AcipHex?
Tell your doctor about all your current medicines and any you start or stop using, especially:

methotrexate (Otrexup, Rasuvo,Trexall); or

warfarin (Coumadin, Jantoven).

This list is not complete. Other drugs may interact with rabeprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Aciphex Side Effects
In Summary
Common side effects of Aciphex include: atrophic gastritis. See below for a comprehensive list of adverse effects.

For the Consumer
Applies to rabeprazole: oral capsule delayed release, oral tablet enteric coated


Along with its needed effects, rabeprazole (the active ingredient contained in Aciphex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rabeprazole:

Less common
Bloating or swelling of the face, arms, hands, lower legs, or feet
cough or hoarseness
dark urine
dry mouth
fever or chills
general tiredness and weakness
light-colored stools
lower back or side pain
nausea and vomiting
painful or difficult urination
rapid weight gain
tingling of the hands or feet
unusual weight gain or loss
yellow eyes and skin
Rare
Bloody urine
continuing ulcers or sores in the mouth
convulsions (seizures)
difficulty with breathing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Incidence not known
Back, leg, or stomach pains
bleeding gums
blood in the urine or stools
bloody, black, or tarry stools
change in consciousness
clay-colored stools
cloudy urine
confusion about identity, place, person, and time
continuing nausea or vomiting
difficulty with swallowing
dizziness
drowsiness
fast heartbeat
general body swelling
general feeling of tiredness or weakness
greatly decreased frequency of urination or amount of urine
headache
high fever
hives, itching, or skin rash
holding false beliefs that cannot be changed by fact
increase in the frequency of seizures
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
loss of consciousness
mood or mental changes
muscle cramps
muscle pain or stiffness
muscle spasms (tetany) or twitching
no blood pressure
no breathing
no pulse
nosebleeds
pale skin
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
seeing, hearing, or feeling things that are not there
skin blisters
sores, ulcers, or white spots on the lips or in the mouth
swollen glands
tightness in the chest
trembling
unpleasant breath odor
unusual excitement, nervousness, or restlessness
vomiting of blood


Some side effects of rabeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bad, unusual, or unpleasant (after) taste
change in taste
Less common
Body aches or pain
congestion
constipation
diarrhea
excess air or gas in the stomach or intestines
feeling weak
full feeling
heartburn
numbness, tingling, pain, or weakness in the hands or feet
pain
passing gas
runny nose
sleepiness
swollen joints
tender, swollen glands in the neck
voice changes
Incidence not known
Blistering, peeling, or loosening of the skin
red, irritated eyes
red skin lesions, often with a purple center
For Healthcare Professionals
Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release

General
The most commonly reported side effects are headache, diarrhea, and abdominal pain.[Ref]

Gastrointestinal
Very common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)
Common (1% to 10%): Nausea, constipation, flatulence, benign fundic gland polyps
Uncommon (0.1% to 1%): Dyspepsia, dry mouth, eructation
Rare (0.01% to 0.1%): Gastritis, stomatitis
Postmarketing reports: Clostridium difficile-associated diarrhea[Ref]

Other
Common (1% to 10%): Infection, non-specific pain, influenza-like illness, asthenia
Uncommon (0.1% to 1%): Chills, pyrexia/fever
Postmarketing reports: Sudden death, facial swelling[Ref]

Respiratory
Common (1% to 10%): Cough, pharyngitis, rhinitis
Uncommon (0.1% to 1%): Bronchitis, sinusitis
Postmarketing reports: Dyspnea, interstitial pneumonia[Ref]

Nervous system
Common (1% to 10%): Headache, dizziness, taste disturbance/perversion
Uncommon (0.1% to 1%): Somnolence, hepatic encephalopathy
Postmarketing reports: Coma, vertigo[Ref]



Hepatic encephalopathy occurred in patients with underlying cirrhosis.[Ref]

Musculoskeletal
Common (1% to 10%): Back pain, myalgia
Uncommon (0.1% to 1%): Leg cramps, arthralgia, fracture of hip/wrist/spine
Postmarketing reports: Rhabdomyolysis, bone fractures[Ref]

Dermatologic
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Erythema
Rare (0.01% to 0.1%): Pruritus, sweating, bullous reactions
Very rare (less than 0.01%): Erythema multiforme, toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome
Frequency not reported: Subacute cutaneous lupus erythematosus
Postmarketing reports: Urticarial skin eruptions, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, fatal TEN[Ref]

Erythema and bullous reactions usually resolved after discontinuation.[Ref]

Psychiatric
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Nervousness
Rare (0.01% to 0.1%): Depression
Frequency not reported: Confusion
Postmarketing reports: Disorientation, delirium[Ref]

Cardiovascular
Common (1% to 10%): Chest pain
Frequency not reported: Peripheral edema
Postmarketing reports: Hypotension[Ref]

Hepatic
Uncommon (0.1% to 1%): Increased hepatic enzymes
Rare (0.01% to 0.1%): Hepatitis, jaundice[Ref]

Increased hepatic enzymes occurred in patients with underlying cirrhosis.[Ref]

Genitourinary
Uncommon (0.1% to 1%): Urinary tract infection[Ref]

Hematologic
Rare (0.01% to 0.1%): Neutropenia, leukopenia, thrombocytopenia, leukocytosis
Postmarketing reports: Pancytopenia, agranulocytosis, bicytopenia, hemolytic anemia, increase in prothrombin time/INR[Ref]

Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.[Ref]

Metabolic
Rare (0.01% to 0.1%): Anorexia, weight gain
Frequency not reported: Hypomagnesemia, hyponatremia
Postmarketing reports: Hyperammonemia[Ref]

Renal
Rare (0.01% to 0.1%): Interstitial nephritis[Ref]

Ocular
Rare (0.01% to 0.1%): Visual disturbance
Postmarketing reports: Blurred vision[Ref]

Endocrine
Frequency not reported: Gynecomastia
Postmarketing reports: TSH elevations[Ref]

Hypersensitivity
Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.[Ref]



Rare (0.01% to 0.1%): Hypersensitivity
Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema[Ref]

References
1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Aciphex (rabeprazole)" Janssen Pharmaceuticals, Titusville, NJ.

Some side effects of Aciphex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.