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Strength Price (Per Unit) Click Below For Prices

2 mg

$0.62  -  $1.09

4 mg

$1.07  -  $1.32

8 mg

$1.67  -  $2.33

Online Avandia prices listed are typically lower than those found on other popular price comparison websites. You will find international and Canadian online pharmacy prices, in addition to U.S. pharmacy prices available with a prescription discount card, for brand and generic medications.

What is Avandia?

Avandia (rosiglitazone) is an oral diabetes medicine that helps control blood sugar levels.

Avandia is for people with type 2 diabetes. Rosiglitazone is sometimes used in combination with other medicines, but it is not for treating type 1 diabetes.

Avandia is not recommended for use with insulin. Taking Avandia while you are using insulin may increase your risk of serious heart problems.

Avandia may also be used for purposes not listed in this medication guide.

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Important information
You should not use Avandia if you have severe or uncontrolled heart failure. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Avandia is not for treating type 1 diabetes.

Avandia can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

Before taking this medicine
You should not use Avandia if you are allergic to rosiglitazone, or if you have severe or uncontrolled heart failure. Do not use Avandia if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure Avandia is safe for you, tell your doctor if you have:

congestive heart failure, heart disease, a history of heart attack or stroke;

fluid retention;

eye problems caused by diabetes; or

liver disease.

Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking Avandia. Talk with your doctor if you are concerned about this possibility.

It is not known whether Avandia will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Some women using Avandia have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

It is not known whether rosiglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Avandia is not approved for use by anyone younger than 18 years old.

How should I take Avandia?
Take Avandia exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take the medicine with or without food.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Use Avandia regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Avandia is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

See also: Dosage Information (in more detail)

What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid?
Avoid drinking alcohol. It can lower your blood sugar.

Avandia side effects
Get emergency medical help if you have any signs of an allergic reaction to Avandia: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

shortness of breath (even with mild exertion), swelling, rapid weight gain;

changes in your vision;

chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or;

pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating.

Common Avandia side effects may include:

headache; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Avandia?
Tell your doctor about all your current medicines, and those you start or stop using during your treatment with Avandia, especially:


heart or blood pressure medicine; or

cholesterol-lowering medicine.

This list is not complete and many other medicines may increase or decrease the effects of Avandia on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
For the Consumer
Applies to rosiglitazone: oral tablet

Along with its needed effects, rosiglitazone (the active ingredient contained in Avandia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rosiglitazone:

Less common
Abdominal or stomach pain
blurred vision
chest pain or discomfort
decrease in the amount of urine
dry mouth
flushed, dry skin
fruit-like breath odor
increased hunger
increased thirst
increased urination
irregular heartbeat
noisy, rattling breathing
pain in the shoulders, arms, jaw, or neck
pale skin
rapid or unusual weight gain
swelling of the fingers, hands, feet, or lower legs
trouble breathing
unexplained weight loss
unusual bleeding or bruising
unusual tiredness or weakness
cold sweats
dark urine
fast heartbeat
loss of appetite
slurred speech
Incidence not known
Blue lips and fingernails
changes in vision
coughing that sometimes produces a pink frothy sputum
hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
itching or skin rash
light-colored stools
redness of the skin
yellow eyes or skin

Some side effects of rosiglitazone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Ear congestion
general feeling of discomfort or illness
hoarseness or other voice changes
joint pain
muscle aches and pains
runny or stuffy nose
sore throat
trouble sleeping
Less common
Back pain
pain or tenderness around the eyes and cheekbones
For Healthcare Professionals
Applies to rosiglitazone: oral tablet

The most commonly reported adverse reports included upper respiratory tract infections, injury, and headache.[Ref]

Major Adverse Cardiovascular Events:
Overall data from long-term rosiglitazone (the active ingredient contained in Avandia) trials including the RECORD, ADOPT, and DREAM trials (rosiglitazone n=6311; control n=7756) showed no difference in overall mortality or major adverse cardiovascular events; however, a meta-analysis of shorter-term trials suggests and increased risk for myocardial infarction with rosiglitazone compared with placebo.

The RECORD trial (Rosiglitazone evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes) revealed no significant difference in cardiovascular hospitalization or cardiovascular death (primary outcome) among patients with type 2 diabetes receiving rosiglitazone add-on therapy (n=2220) compared with active control (n=2227); however, there was a significant difference in the incidence of CHF (secondary endpoint). Patients randomized were those who had failed metformin or sulfonylurea monotherapy; mean age: 58 years; 52% male. Following randomization to add-on rosiglitazone or active control (add-on metformin for those inadequately controlled on sulfonylurea or add-on sulfonylurea for those inadequately controlled on metformin) patients were treated to a target glycosylated hemoglobin (HbA1c) of 7% or less. Heart failure was reported in 61 patients receiving add-on rosiglitazone and 29 patients receiving active control.

In a retrospective analysis of 42 clinical trials (mean duration 6 months), rosiglitazone was associated with an increased risk of myocardial ischemia compared with combined active or placebo control (2% versus 1.53%). These events included angina pectoris, angina dyspnea, myocardial infarction, coronary thrombosis, myocardial ischemia, coronary artery disease, and coronary artery disorder. There was an increased risk with combination insulin therapy and in patients receiving nitrates for known coronary heart disease.

Cardiovascular Events in Patients with NYHA Class I and II Heart Failure:
An increased risk of cardiovascular events was observed in a 52-week trial in patients with NYHA Class I and II Heart Failure who were receiving rosiglitazone (n=110) compared with placebo (n=114). These events included: cardiovascular deaths (5% vs 4%), worsening CHF (6% vs 4%), new or worsening edema (25% vs 9%), new or worsening dyspnea (26% vs 17%), increases in CHF medication (33% vs 18%), and cardiovascular hospitalization (19% vs 13%).

-Dose-related edema was reported in rosiglitazone clinical trials. In patients receiving rosiglitazone 8 mg in combination with a sulfonylurea, the incidence of edema was 12.4%. In rosiglitazone monotherapy trials, edema was reported in 4.8% of patients (dose not specified). Healthy volunteers receiving rosiglitazone 8 mg once daily for 8 weeks experienced a statistically significant increase in median plasma volume compared with placebo.

Concomitant Administration with Insulin:
-Edema was reported with higher frequency in the rosiglitazone plus insulin combination trials (insulin, 5.4%; and rosiglitazone with insulin 14.7%). Reports of new onset or exacerbation of CHF occurred at a rate of 1% for insulin alone, 2% (4 mg) and 3% (8 mg) for insulin in combination with rosiglitazone. The coadministration of rosiglitazone and insulin is not recommended.[Ref]

Common (1% to 10%): Edema, hypertension,
Frequency not reported: Cardiovascular deaths, congestive heart failure (CHF), myocardial infarction, angina, angina pectoris, angina dyspnea, myocardial infarction, coronary thrombosis, myocardial ischemia, coronary artery disease, coronary artery disorder[Ref]

Anemia was reported in 1.9% of patients receiving rosiglitazone (the active ingredient contained in Avandia) as monotherapy. In combination therapy with metformin, a sulfonylurea, or metformin plus a sulfonylurea, the incidence of anemia was 7.1%, 2.3%, and 6.7%, respectively. Laboratory findings have shown dose-related decreases in hemoglobin and hematocrit; mean decreases in hemoglobin were 1 g/dL and up to 3.3% in hematocrit. These changes primarily occurred during the first 3 months or following a dose increase. They may be related to increased plasma volume.[Ref]

Common (1% to 10%): Anemia
Frequency not reported: Decrease in WBC counts[Ref]

Uncommon (0.1% to 1%): Hyperbilirubinemia, ALT elevations
Postmarketing reports: Hepatitis, hepatic enzyme elevations greater than 3 times the upper limit of normal, hepatic failure[Ref]

Common (1% to 10%): Hyperglycemia, hypoglycemia, hypocholesterolemia
Uncommon (0.1% to 1%): Weight gain
Frequency not reported: Increases in waist and hip circumference[Ref]

The mechanism of weight gain is unclear, although it probably is due to a combination of fluid retention and fat accumulation. In the ADOPT monotherapy trial, median weight change at 4 years was plus 3.5 kg.[Ref]

Frequency not reported: Resumption of ovulation in premenopausal, anovulatory women, hormonal imbalance[Ref]

Postmarketing reports: Anaphylactic reaction, urticaria, angioedema[Ref]

Postmarketing reports: Rash, pruritus, urticaria, angioedema, Stevens-Johnson syndrome[Ref]

Postmarketing reports: Diabetic macular edema with decreased visual acuity[Ref]

Common (1% to 10%): Upper respiratory tract infection, sinusitis
Frequency not reported: Dyspnea
Postmarketing reports: Pulmonary edema, pleural effusions[Ref]

Common (1% to 10%): Back pain
Frequency not reported: Fractures[Ref]

Long-term clinical trials have shown an increased incidence of bone fracture in patients receiving drug compared with glyburide or metformin. This increased incidence appeared after the first year and persisted during the trials. The majority of fractures were observed in women and occurred in the upper arm, hand, and foot.[Ref]

Common (1% to 10%): Diarrhea[Ref]

Common (1% to 10%): Injury, fatigue[Ref]

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Avandia (rosiglitazone)" SmithKline Beecham, Philadelphia, PA.

Some side effects of Avandia may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.